Lung Cancer Related to Wood-Smoke Exposure

June 7, 2012 · 2 comments

Journal of Thoracic Oncology: 31 May 2012

Clinical and Pathological Characteristics, Outcome and Mutational Profiles Regarding Non-Small-Cell Lung Cancer Related to Wood-Smoke Exposure

Arrieta, Oscar, et al.

Hypothesis: Although smoking is the major risk factor for non-small-cell lung cancer (NSCLC), other factors are also associated with lung carcinogenesis, such as wood-smoke exposure (WSE). This article has been aimed at suggesting that lung cancer related to cigarette smoking and lung cancer related to WSE have different clinical and genetic characteristics.

Experimental Design: A cohort of 914 lung cancer patients was prospectively studied; they had been treated at Mexico’s National Cancer Institute between 2007 and 2010. The associations of WSE and cigarette smoking with clinical characteristics, mutation profile, response to chemotherapy, and epidermal growth factor receptor tyrosine kinase inhibitors were analyzed, and overall survival (OS) rate was calculated. The trial was registered with NCT01023828.

Results: Of the lung cancer patients studied, 95.1% were classified as coming within the NSCLC histology subtype; 58% of the patients smoked cigarettes, 35% had a background of WSE (exposure to both cigarette smoke and wood smoke was documented in 12.1% of all patients), and 19.4% patients had no smoke-exposure background. WSE was associated with NSCLC and adenocarcinoma histology, and was also more frequently associated with epidermal growth factor receptor-mutations than cigarette-smoking patients were (50.0% cf. 19.4%), whereas KRAS mutations were less common in WSE patients (6.7%) than in smokers (21%). WSE patients had a higher epidermal growth factor receptor tyrosine kinase inhibitor response rate (39.7%) than smokers (18.8%). The NSCLC patient WSE group’s OS was longer (22.7 months) than that for smokers (13.8 months).

Conclusion: NSCLC patients who smoked tobacco/cigarettes differed from those having a background of WSE regarding tumor histology, mutation profile, response rate, and OS, indicating that different carcinogenic mechanisms were induced by these two types of smoke exposure.

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{ 2 comments… read them below or add one }

Clive Stott June 8, 2012 at 6:24 am

Thank you very much to those involved in this study.
Very interesting results.


Air Is Precious July 24, 2012 at 12:47 pm

The millions who are ill and suffering from Woodsmoke exposure welcome and encourage the reseach being done in this study.

Woodsmoke has a negative, toxic impact on our health and our environment . The more people begin to grasp the complex nature of Woodsmoke’s toxic chemicals and the links to our health, will in time perhaps encourage our leaders to take further pro-active action to eliminate such a deadly source of airborne pollution in our urban communities.

There can be no denial that exposure to Woodsmoke is linked to so many health issues being faced by millions world-wide.

Thank you for this study and the results released.


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